The Buick LeSabre was a full-size car made by the Buick division of General Motors from 1959-2005. For many years, the LeSabre was considered the entry level full-size Buick, carrying the lowest base price in the Buick lineup. Prior to 1959, that position had been held by the full-size Buick Special model; in 1959 the LeSabre replaced the Special, a nameplate that was reintroduced in 1961 for Buick's line of compact cars.

LeSabre carried the title of America's Best-Selling Full-size Car until its demise at the end of the 2005 model year. The car was replaced with the 2006 Buick Lucerne. The last LeSabre rolled off the Lake Orion, Michigan assembly line on June 18, 2004 (retooling the plant to build the Pontiac G6) and the last Hamtramck, Michigan LeSabre rolled off the assembly line on July 22, 2005.