The Cadillac DTS (DeVille Touring Sedan) is a full-size luxury sedan from the Cadillac luxury division of General Motors. The DTS replaces the Cadillac DeVille as that carmaker's largest luxury car for MY 2006, following the naming and styling direction set by the earlier CTS and STS. The design of the DTS was introduced in a unique way. A specially designed and outfitted presidential DTS limousine was utilized during the second inauguration of George W. Bush in the January 20, 2005 parade. While details of the vehicle, codenamed Stagecoach, are highly classified, it is presumed to be heavily armored and feature advanced communication equipment. The DTS is manufactured at GM's Detroit/Hamtramck Assembly factory in Hamtramck, Michigan.

The Cadillac DTS is the largest sedan that General Motors offers. Along with the STS sedan, Cadillac has confirmed that both cars will be discontinued for MY 2010. In an interview with Automotive News, General Motors executives said that they will be replaced with one performance sedan.