Also sharing the Astro's truck-based platform was its sibling, the GMC Safari. In addition to standard passenger uses, the vans were also available as cargo vans, and converters used them as the basis for small conversion vans. Both Pontiac and GMC have used the Safari nameplate (GMC is part of the Pontiac/GMC division); Pontiac used the nameplate on several of its station wagon models from 1955 through 1989. The two Safaris, both Pontiac and GMC, were on the market together (often sold by the same dealerships) from 1985 through 1989.

Faced with falling sales across its vehicle lines, General Motors began closing plants and discontinuing slow-selling vehicle lines. With new federal standards for side impact and head injury reductions coming, GM determined that there was no use in expending money for a redesign of a vehicle line that was no longer selling well. Thus, the Safari and Astro were taken out of production in May 14, 2005, and the long-serving Baltimore, Maryland assembly plant where both were built was closed.